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Anti-Histone H3 Rabbit mAb

Modulationof chromatinstructureplaysan important role in the regulationoftranscription ineukaryotes. Thenucleosome,madeupofDNAwoundaroundeightcorehistoneproteins(twoeachofH2A,H2B,H3,andH4), istheprimarybuildingblockof chromatin.HistoneH3 isprimarilyacetylatedatLys9, 14, 18,23, 27, and56.AcetylationofH3at Lys9appears tohaveadominant role in histonedepositionandchromatinassemblyinsomeorganisms.PhosphorylationatSer10,Ser28,andThr11ofhistoneH3istightlycorrelatedwithchromosomecondensationduringbothmitosisandmeiosis.

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